Fungal infections are a common problem that affects millions of people worldwide. From athlete's foot to nail fungus, these infections can be persistent and difficult to treat. While there are several antifungal medications available, they often come with side effects and may not be effective against all types of fungi. This has led to a growing interest in natural antifungal agents, particularly those derived from plants. One such compound that has shown promise in recent studies is Cis-Isolimonenol, with CAS No. 22972-51-6.
What is Cis-Isolimonenol?
Cis-Isolimonenol is a natural compound found in several plant species, including the essential oils of citrus fruits, conifers, and eucalyptus. It is a colorless liquid with a pleasant, citrusy aroma and is commonly used in perfumes, soaps, and other fragrances. In recent years, researchers have been exploring the potential of Cis-Isolimonenol as a natural antifungal agent.
Antifungal Properties of Cis-Isolimonenol supply
Several studies have investigated the antifungal properties of Cis-Isolimonenol, and the results have been promising. In a study published in the Journal of Agricultural and Food Chemistry, researchers tested the antifungal activity of Cis-Isolimonenol against several common fungal pathogens, including Candida albicans, Aspergillus niger, and Trichophyton mentagrophytes. The results showed that Cis-Isolimonenol was effective against all three fungi, with a minimum inhibitory concentration (MIC) of 0.25-0.5 mg/mL.
Another study published in the Journal of Essential Oil Research investigated the antifungal activity of Cis-Isolimonenol against dermatophytes, a group of fungi that commonly cause skin and nail infections. The researchers found that Cis-Isolimonenol was effective against all the dermatophytes tested, with MIC values ranging from 0.125 to 0.5 mg/mL.
In addition to its antifungal properties, Cis-Isolimonenol has also been shown to have antibacterial and antioxidant activity. A study published in the Journal of Agricultural and Food Chemistry found that Cis-Isolimonenol was effective against several strains of bacteria, including Staphylococcus aureus and Escherichia coli. The compound also exhibited strong antioxidant activity, which could help protect against oxidative damage caused by free radicals.
Mechanism of Action
The exact mechanism of action of Cis-Isolimonenol against fungi is not yet fully understood. However, several studies have suggested that it may disrupt the fungal cell membrane, leading to cell death. In a study published in the Journal of Essential Oil Research, researchers found that Cis-Isolimonenol caused significant damage to the cell membrane of dermatophytes, which may explain its antifungal activity.
Another study published in the Journal of Agricultural and Food Chemistry investigated the effects of Cis-Isolimonenol on the biofilm formation of Candida albicans, a common fungal pathogen. Biofilms are communities of microorganisms that can form on surfaces, including medical devices and tissues, and are often resistant to conventional antifungal treatments. The researchers found that Cis-Isolimonenol was able to inhibit the formation of Candida albicans biofilms, suggesting that it may be effective against biofilm-associated infections.
Safety and Toxicity
While Cis-Isolimonenol has shown promising antifungal activity, its safety and toxicity profile have not been extensively studied. However, several studies have suggested that it is relatively safe and non-toxic. In a study published in the Journal of Agricultural and Food Chemistry, researchers found that Cis-Isolimonenol was not cytotoxic to human skin cells at concentrations up to 0.5 mg/mL. Another study published in the Journal of Essential Oil Research found that Cis-Isolimonenol was not mutagenic or genotoxic in bacterial and mammalian cell assays.
Conclusion
Fungal infections are a common problem that can be difficult to treat with conventional antifungal medications. However, natural compounds such as Cis-Isolimonenol may offer a promising alternative. Several studies have shown that Cis-Isolimonenol has potent antifungal activity against a range of fungal pathogens, including dermatophytes and biofilm-forming fungi. While its safety and toxicity profile have not been extensively studied, the available evidence suggests that it is relatively safe and non-toxic. Further research is needed to fully understand the mechanism of action of Cis-Isolimonenol and its potential as a natural antifungal agent.
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